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KMID : 0387420080190030069
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Korean Society of Oriental Neuropsychiatry
2008 Volume.19 No. 3 p.69 ~ p.84
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The Effects of KakamBoyangHwanohTang(KBHT) Hot Water Extract & Ultra-fine Powder on the Alzheimer’s Disease Model
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Seo Seung-Ho
Jung In-Chul
Lee Sang-Ryong
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Abstract
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Objective: This experiment was designed to investigate the effects of the KBHT hot water extract & ultra-fine powder on Alzheimer’s Disease Model Induced by A.
Method: The effects of the KBHT hot water extract on expression of proinflammatory cytokine mRNA in BV2 microglial celll cell line treated by lipopolysacchaide(LPS). The effects of the KBHT hot water extract & ultra-fine powder on (1) the behavior (2) AChE in serum (3) the infarction area of the hippocampus, and brain tissue injury in Alzheimer’s diseased mice induced with A were investigated.
Results: 1. The KBHT hot water extract suppressed the expression of proinflammatory cytokine mRNA in BV2 microglial cell line treated with LPS. 2. The KBHT hot water extract & ultra-fine powder a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer’s disease induced by A in the Morris water maze experiment, which measured stop-through latency and distance movement-through latency 3. The KBHT hot water extract & ultra-fine powder suppressed the over-expression of AChE activity in the serum of the mice with Alzheimer’s disease induced by A. 4. The KBHT hot water extract & ultra-fine powder suppressed the expression of TNF-, IL-l protein significantly in the microglial cell of mice with Alzheimer’s disease induced by 1A. 5. The KBHT ultra-fine powder reduced infarction area of hippocampus significantly in the mice with Alzheimer’s disease induced by A.
Conclusions: These results suggest that the KBHT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer’s disease. Investigation into the clinical use of the PMCMT hot water extract & ultra-fine powder for Alzheimer’s disease is suggested for future research.
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KEYWORD
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Alzheimer’s disease, KakamBoyangHwanohTang(KBHT), hot water extract, ultra-fine powder
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